A Review of Bioequivalence Testing for Reclamation of Strip Mined Sites

ABSTRACT
In the demanding world of the 21st century, everything changes and evolves. What was right yesterday, might not be today. Statistics is not exception to these rules. This paper introduces the term bioequivalence, explains how it might be used by the Department of Environmental Quality, and it also compares the classical null hypothesis with the bioequivalence test.  Specifically, this paper tries to look at the possible problems with the classical null hypothesis, and why bioequivalence testing might be a preferred method when dealing with the bond release data. Currently, the state of Wyoming is in the process of reviewing and re-writing the Appendix A of the Coal Mine’s Rules and Regulations. We would like to provide a scientific basis for changes in this Appendix.   By the means of simulation, we will try show when and why the bioequivalence might be a preferred method over the classical null hypothesis. The data sets used in the project were provided by the states of Wyoming, Colorado, and New Mexico.

College of Natural Sciences