General Semiparametric Analysis of Repeated Measures Data 
Raymond J. Carroll, Distinguished Professor
Departments of Statistics and Nutrition and Toxicology
Texas A&M University
Monday, May 1, 2006
4:10 p.m.
E205 Engineering Building
ABSTRACT
This talk considers the general problem where the data for an individual are repeated measures in the most general sense, with a parametric component and a nonparametric component. It is easy, although not wellknown, to handle the problem in the case that the nonparametric component of the likelihood function is evaluated exactly once, e.g., when a baseline variable is modeled nonparametrically. Far more difficult, and nonintuitive, is the case where the nonparametric component is evaluated more than once in the likelihood function. Examples include repeated measures studies, variance component models when the random effect is related to the predictors, matched casecontrol studies with a nonparametric component, fixedeffects models in econometrics, etc. I will present a constructive (i.e., computable), semiparametric efficient method for this general problem. The constructive part is important: like most semiparametric efficient methods, there is an integral equation lurking in the background, but unlike most such methods, in our approach the integral equation can be avoided. An example involving caloric intake and income in China is used to illustrate the methodology.
